Chemotherapy for Breast cancer

Chemotherapy is not for every patient with breast cancer. Actually, the majority of breast cancer patients will never have chemotherapy. It is mainly for: 

  • Patients who have high-risk cancer that has been (or will be) removed completely by surgery and
  • Some patients with stage 4 (or metastatic) breast cancer.

High-risk breast cancer:

This includes cancers that have not spread outside the breast and nearby lymph nodes, but the risk of them coming back after surgery is high. In this case, we use chemotherapy either:

  • After surgery to destroy any cancer cells that may have been left behind after surgery or
  • Before surgery to reduce the size of breast cancer and make surgery more successful. This may enable surgeons to avoid doing a mastectomy by reducing the size of the area they are going to remove.

Either way, chemotherapy will destroy cancer cells that may have spread to other parts of the body like liver or lung. These tiny cancer cells that cannot be usually detected on scans have the ability to start dividing, growing and spreading any time in the future.

Stage-4 breast cancer:

Although stage-4 breast cancer cannot be cured, treatment may keep it in remission (dormant) for a number of years. We may use chemotherapy, but we may also use endocrine treatment, targeted therapy and sometimes radiotherapy to slow the progression of the disease and improve patients’ quality of life.

Chemotherapy can achieve rapid response but is toxic and may sometime worsen patients’ quality of life. Therefore, we use it for cancers that are growing fast and we want to achieve a quick and effective response. We are also likely to use it when breast cancer is not sensitive to endocrine therapy.

Chemotherapy facts:

  • There are many types of chemotherapy drugs, some based on natural plant compounds and others using man-made chemicals.
  • Chemotherapy drugs can be given on its own or in combination with other chemotherapy drugs.
  • Chemotherapy is given in three-weekly (once every three weeks) cycles.
  • A cycle is the day of chemo administration and the following three weeks which are usually given to allow recovery from chemotherapy side effects.
  • The majority of chemotherapy drugs are given intravenously but some of them are given orally as tablets.
  • Chemotherapy can be combined with targeted therapy but not with endocrine treatment.
  • Not all chemotherapy drugs cause hair loss.




Here you will find a list of the most common chemotherapy drugs used for treating Breast cancer. Please click on the link to read more about each drug.






Gemcitabine and Carboplatine


Pertuzumab, trastuzumab and docetaxel


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